VERY COMMON

Bleeding from the nose that lasts for more than 10-15 minutes and cannot be stopped

Diarrhea

Vomiting

Constipation

Bleeding from the rectum or stomach: Symptoms include fresh blood in stools and/or dark stools

Decreased number of white blood cells: Symptoms could include fever, sore throat, infection

Decreased number of red blood cells in the blood that carry oxygen: Symptoms could include feeling of weakness or fatigue in general or during exercise, poor concentration

Pain: chest pain, back pain, abdominal pain, muscle pain, joint pain

Low blood pressure: You may not experience any symptoms, but possible symptoms associated with low blood pressure are: lightheadedness, dizziness, fainting

Dilation (widening of the blood vessels): Symptoms may include low blood pressure, dizziness, flushing

Weakened heart muscle/loss of the heart’s pumping ability: shortness of breath, fatigue, persistent coughing or wheezing, increased heart rate, swelling in the feet or ankles

Eye problems: for example: excessive tearing, blurred vision, an experience of discomfort or pain to the eyes

Bronchitis: an inflammation of the main air passages to the lungs

Infections: mouth, throat, sinus, lungs or urine infections

Excess of sugar in the blood: symptoms may include frequent hunger, frequent thirst, frequent urination

Coughing

COMMON

Perforation of the gut (leakage of the bowel): sudden onset of abdominal pain, abdominal tenderness with vomiting, high fever, constipation, vomiting  

Allergic reactions: difficulty in breathing, chest pain, redness or flushing of the skin, rash, shivering, nausea, vomiting

Urinary (bladder or kidney) infection

Infections of the skin or deeper layers under the skin

Fistula: abnormal tube-like connection between internal parts of the body that are not normally connected such as between the stomach and the intestines (gastrointestinal fistula), in patients with metastatic colorectal cancer and recurrent ovarian cancer, and the vagina and the gut in patients with cervical cancer (unauthorized use)

Blood clots: In the deep veins of the leg, symptoms include: pain, swelling, warm to the touch, and tenderness of the leg. In the lung, symptoms include: shortness of breath, chest pain, light headedness

Stroke or heart attack: Symptoms of stroke include: sudden loss of speech or numbness of part or all of the body, loss of vision or blurred vision, unexplained dizziness and/or sudden falls. Symptoms of a heart attack include: chest pain with spreading to the left arm, jaw and/or back, shortness of breath

Hemorrhage: gastrointestinal bleeding, significant blood in vomit, bleeding from rectum or stomach (fresh blood in stools or dark stool), bleeding from the nose that lasts more than 10-15 minutes and cannot be stopped, spitting of blood

Wounds opening and not healing: the skin near a surgical area can appear fully or partially open

Nephrotic syndrome: swelling in the face, arms, legs, belly area, foamy appearance of urine and poor appetite

Pain: in the pelvis and anal regions

UNCOMMON

Non-gastrointestinal perforations and fistulae: Depending on the organs involved, the symptoms could be: leakage of urine, abnormal and bad odor in the genital area, abdominal pain, vomiting, fever, gradually increasing/worsening of shortness of breath (dyspnoea), cough, chest pain, yellowish discoloration of the skin, etc.

Posterior Reversible Encephalopathy Syndrome (PRES): headache, confusion, seizures and visual loss

RARE

Tracheoesophageal fistula: abnormal tube like connection between internal parts of the body that are not normally connected) such as between the trachea (or windpipe) and esophagus (tube connecting the mouth to the stomach)

Severe bacterial infection of the skin and soft tissue: necrotizing fasciitis

Bleeding: in the brain

FREQUENCY UNKNOWN

Jaw bone damage resulting from poor blood supply to the jaw bone

Perforation in the gallbladder: hole in the digestive organ that stores bile